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Fa-IgA nephropathy (IgAN) is a kidney disease recognized by the presence of IgA antibody depositions in kidneys. The underlying mechanisms of this complicated disease are remained to be explored and still, there is an urgent need for the discovery of noninvasive biomarkers for its diagnosis. In this investigation, an integrative approach was applied to analyze two microarray datasets including mRNA and miRNA expression profiles in PBMCs to discover a gene signature and novel potential targets/biomarkers in IgAN.
Our recent review article entitled " Cancer regeneration: polyploid cells are the key drivers of tumor progression" is know publicly available at BBA Reviews on Cancer Journal.
In this article we suggest that polyploidy as an evolutionary conserved mechanism shares similar functions both in regeneration and tumor progression, one as a friend and the other as a foe! Considering therapeutic approaches killing polyploid giant cancer cells is urgent for overcoming cancer relapse.Our recent review article entitled " Cancer regeneration: polyploid cells are the key drivers of tumor progression" is know publicly available at BBA Reviews on Cancer Journal.
In this article we suggest that polyploidy as an evolutionary conserved mechanism shares similar functions both in regeneration and tumor progression, one as a friend and the other as a foe! Considering therapeutic approaches killing polyploid giant cancer cells is urgent for overcoming cancer relapse.
